� it the levels of iep, zn and changed after dialysis, due to the removal of molecules that were poorly linked mainly avapro certificate free peg at the outer part of the surface, avapro certificate allowing viagra company info accessibility to the inner adjacent part of the shell water shell fig accessible layer to counter ions characterized by its thickness x and its dipolar charge density avapro certificate zn nm lnc presented the bestorganized and the accessible avapro certificate part of the shell, compared with other sizes of avapro certificate lnc, before and after dialysis lecithin was found to be present in the inner part of the polyelectrolyte layer and was found to play a role in the disorganization of the outer part dialyzing lnc formulated with lecithin led to stable and well structured nanocapsules, ready for avapro certificate an in vivo use as a drug delivery system avapro certificate evaluation of complement system avapro certificate activation generally, after intravenous administration, nanoparticles np are rapidly removed from the blood stream because they are recognized by cells of the mps such as kiipffer cells in the liver, or spleen and bonemarrow macrophages however, a avapro certificate brush of peg chains grafted avapro certificate on the surface is known avapro certificate to decrease the recognition of nanoparticles by the immune system after intravenous administration one has demonstrated that a strong correlation prevails between the avapro certificate complement activation and the stealthy properties of lnc therefore, these properties were evaluated by measuring the degree of avapro certificate complement activation [ch technique and crossed immunoelectrophoresis c cleavage] and the level of macrophage uptake, in relation to the organization of peg chains, according to the electrokinetic properties of the lnc surface these experiments were performed on , and nm lnc before and after dialysis the ch technique is presented in fig nanoparticles are dispersed in human avapro certificate serum with sensitized erythrocytes after avapro certificate incubation, lysis is evaluated by a classical spectrophotometric method the measured absorbance is related to the consumption of complement proteins by particles the avapro certificate main conclusions are that whatever the in vitro test, all lnc were not recognized by the non specific components of the immune system it was probably due to the strong density of peg chains at their surface avapro certificate furthermore, dialysis maintains a avapro certificate sufficiently high density of peg avapro certificate and had no incidence on the complement consumption pharmacokinetic avapro certificate studies and biodistribution at first, the biodistribution of radiolabeled nanocapsules was studied by scintigraphy and � counting, after intravenous avapro certificate administration in rat whereby the mtcoxine was incorporated in the lipid core and i labelled the shell of the nanocapsules dynamic scintigraphic acquisition avapro certificate was carried out hrs after administration and � activity in blood and tissues was followed for more than avapro certificate hrs see fig an early halfdisappearance time of about � min was found for avapro certificate i and � min for mtc these ranges cardizem acetate of residence avapro certificate times were interesting for specific �a st active wcd�s vcub nnnnil scrum cdds vr i ?