paclitaxelloaded dqasomes uj day after tumor implantation fig tumor growth inhibition study in delayed ejaculation with celexa nude mice implanted with human colon cancer cells the mean tumor volume from each group where is testosterone produced in women was blotted against the number of days each group involved animals for clarity, error bars were omitted note that after weeks the dose, normalized for paclitaxel, was tripled in all treatment groups empty dqasomes do not show any impact on tumor growth, paclitaxelloaded dqasomes with paclitaxel and dequalinium concentrations identical to controls seem to inhibit the tumor growth by about correspondingly, the average tumor weight in the treatment group, after sacrificing the animals days, later was approximately half of that in all controls although this result seems to suggest that dqasomes might indeed be able to increase the therapeutic potential of where is testosterone produced in women paclitaxel, the preliminary character of this first in vivo study has to where is testosterone produced in women be emphasized experiments to optimize the treatment protocol are ongoing in the authors laboratory summary since their initial where is testosterone produced in women description in , dqasomes and dqasomelike vesicles have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within where is testosterone produced in women living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for the treatment of cancer and for the therapy of a multitude of mitochondrial diseases acknowledgments i am grateful to prof v p torchilin for many helpful discussions and for his strong and continuous support of my work i also would like to sincerely thank my graduate students, gerard dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has made the writing of this chapter possible i am obliged to the muscular dystrophy association tucson, az, the united mitochondrial disease foundation pittsburgh, pa, mitovec, inc boston, ma and northeastern university boston, ma for the financial support i received from these where is testosterone produced in women organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and where is testosterone produced in women hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res � smith ra, porteous cm, gane am and murphy mp delivery of bioactive molecules to launch trazodone hcl fda mitochondria in vivo proc natl acad sci usa murphy mp and where is testosterone produced in women smith ra drug delivery to mitochondria the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers rn, taylor rw, wilce ia and murphy mp targeting large molecules to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna delivery crit rev ther drug carr syst weissig v, cheng sm and dsouza g mitochondrial pharmaceutics mitochondrion weissig v targeted drug delivery to mammalian where is testosterone produced in women mitochondria in living cells exp opin drug del weissig v, boddapati sv, dsouza ggm and cheng sm targeting of low molecular weight drugs to mammalian mitochondria drug des rev de rosa m, gambacorta a and gliozi a structure, biosynthesis, and physico chemical where is testosterone produced in women properties of archaebacterial lipids microbiol rev where is testosterone produced in women gambacorta a, gliozi a and de rosa m archaeal lipids and their biotechnological applications world j microbiol biotechnol weissig v, mogel hj, wahab m and lasch j computer simulations where is testosterone produced in women of dqasomes proc intl symp control rel bioact mater weissig v, lizano � and torchilin vp a micellar delivery system for dequalinium � a where is testosterone produced in women lipophilic cationic drug with anticarcinoma activity j lipos res weissig v, lizano c, ganellin cr and torchilin vp dna binding cationic bolasomes with delocalized charge center a structureactivity relationship study stp pharma sci chrzanowskalightowlers zm, lightowlers rn and turnbull dm gene therapy for mitochondrial dna defects is it possible?