paclitaxelloaded dqasomes uj day naltrexone and university of penn after tumor implantation fig tumor growth inhibition study in nude mice implanted naltrexone and university of penn with human colon cancer cells the mean tumor volume from each group naltrexone and university of penn was blotted against the number of days each group involved animals for clarity, error bars were omitted note that after weeks the dose, normalized naltrexone and university of penn for paclitaxel, was tripled in all treatment groups empty dqasomes do not naltrexone and university of penn show any impact on tumor growth, paclitaxelloaded dqasomes with paclitaxel and dequalinium concentrations identical to controls seem to inhibit the tumor growth by about correspondingly, the average tumor weight in the treatment group, after sacrificing the animals days, later was approximately half of that in all controls although this result seems to suggest that dqasomes might indeed be able naltrexone and university of penn to increase the therapeutic potential of paclitaxel, the preliminary character of this first in vivo study has to be emphasized experiments to optimize the treatment protocol are ongoing in the naltrexone and university of penn authors laboratory summary since their initial description in , dqasomes and dqasomelike vesicles have been established as the first naltrexone and gay viagra sex university of penn mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within naltrexone and university of penn living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for the treatment of cancer and for the therapy of a multitude of mitochondrial diseases acknowledgments i am grateful to prof v p torchilin for many helpful discussions and for his strong and continuous support of my work i also would like to sincerely thank my graduate students, gerard dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has naltrexone and university of penn made the writing of this chapter possible i am obliged to the muscular dystrophy association tucson, az, the united mitochondrial disease foundation pittsburgh, pa, mitovec, inc boston, ma and northeastern naltrexone and university of penn university boston, ma for the financial support i received from these organizations during the last four years naltrexone and university of penn references weissig v, lasch j, erdos g, meyer hw, rowe tc and hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res � smith ra, porteous cm, gane am and murphy mp delivery of bioactive molecules naltrexone and university of penn to mitochondria in vivo proc natl acad sci usa murphy mp and smith ra drug delivery to mitochondria the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers rn, taylor rw, wilce ia and naltrexone and university of penn murphy mp targeting large molecules to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna delivery crit rev ther drug carr syst weissig v, cheng sm and dsouza g mitochondrial pharmaceutics mitochondrion weissig v targeted drug delivery to mammalian mitochondria in living cells exp opin naltrexone and university of penn drug del weissig v, boddapati sv, dsouza ggm and cheng sm targeting of low molecular weight drugs to mammalian mitochondria drug des rev de naltrexone and university of penn rosa m, gambacorta a and gliozi a structure, biosynthesis, and physico chemical properties of archaebacterial lipids microbiol rev naltrexone and university of penn gambacorta a, gliozi a and de rosa m archaeal lipids and their biotechnological applications world j microbiol biotechnol weissig v, mogel hj, wahab m and lasch j computer simulations of dqasomes proc intl symp control rel bioact mater weissig v, lizano naltrexone and university of penn � and torchilin vp a micellar delivery system for dequalinium � a naltrexone and university of penn lipophilic cationic drug with anticarcinoma activity naltrexone and university of penn j lipos res weissig v, lizano c, ganellin cr and torchilin vp dna binding cationic bolasomes with delocalized charge center a structureactivity relationship study stp pharma sci chrzanowskalightowlers zm, lightowlers rn and turnbull dm gene therapy for mitochondrial dna defects is it possible?