tv fjsr � � glyburide description peg chains had little influence on glyburide description the encapsulation efficiency of methotrexate, but affected the release rate a similar construct between peg chains and ����� was utilized to deliver the anticancer drug fluorouracil encapsulation of fluorouracil into g = ����� dendrimers with carboxymethyl glyburide description peg surface chains revealed reasonable drug loading, a reduced release rate, and glyburide description reduced hemolytic toxicity compared to the glyburide description nonpegylated dendrimer fig etoposide, mefenamic acid diclofenac, and venlafaxine the combination glyburide description between dendrimers and hydrophilic and or hydrophobic polymer chains has recently been extended to solubilize the hydrophobic anticancer drug etoposide a star polymer composed of amphiphilic block copolymer arms has been synthesized and characterized the core glyburide description of the star polymer was a generation two pamamoh dendrimer, the inner block of the arm a lipophilic polyecaprolactone pcl and the outer block glyburide description of the arm a hydrophilic peg glyburide description the starpcl polymer was synthesized first by ringopening polymerization of ecaprolactone with the pamamoh dendrimer as initiator glyburide description the peg polymer was then attached to the pcl terminus by an esterforming reaction characterization with sec, h glyburide description nmr, ftir, tga, and dsc confirmed the star structure of the polymers a loading capacity of up to ww was achieved with etoposide a glyburide description cytotoxicity assay demonstrated that the starpclpeg glyburide description copolymer was nontoxic in cell culture citric acidpolyethylene glycolcitric acid cpegc triblock dendrimers generations were applied to glyburide description encapsulate small molecule drugs such as mefenamic acid and diclofenac the formulations were stored at room temperature for up to ten months and remained glyburide description stable with no reported release of glyburide description the drugs the attachment of the novel thirdgeneration antidepressant venlafaxine onto anionic glyburide description ����� dendrimers g = via a hydrolyzable ester bond and the incorporation of this drugdendrimer complex into a semiinterpenetrating network of an acrylamide hydrogel has been studied as a novel drug delivery formulation to avoid the currently necessary multiple daily administration of the antidepressant the effect of glyburide description peg concentration and molecular weight was studied to find optimal release conditions glyburide description ibuprofen, indomethacin, nifedipine naproxen, paclitaxel and methylprednisolone the antiinflammatory drug ibuprofen was glyburide description used as a model compound to study its complexation and encapsulation into generations and ����� dendrimers and a hyperbranched polyester, having approximately surface ohgroups it was found that up to glyburide description ibuprofen molecules were complexed by the ����� dendrimers through electrostatic interactions glyburide description between the dendrimer amines and the carboxyl group of the drug in contrast, up to drug molecules were encapsulated into the hyperbranched polyol the drug was successfully transported into a human lung epithelial carcinoma cells by glyburide description the dendrimers the ����� dendrimers with either amino or hydroxy surfaces entered glyburide description the cells faster in approximately hr than the hyperbranched polyol approximately hrs glyburide description however, both entries were faster than the pure drug the antiinflammatory glyburide description effect of ibuprofendendrimer complexes was demonstrated glyburide description by more rapid suppression of cox mrna levels than that achieved by glyburide description the pure drug the nonsteroidal antiinflammatory drug nsaid indomethacin is practically insoluble glyburide description in water and only sparingly soluble in alcohol encapsulation of indomethacin into generation ����� dendrimers with amino, hydroxy, and carboxylate surfaces remarkably enhanced the drug solubility in water, and therefore, glyburide description its bioavailability fig the encapsulation efficiency glyburide description of indomethacin into ����� dendrimers glyburide description is dependent on the dendrimer size g g g g and the surface functionalization, nh peg = pyr ae fig the effect of ����� tegretol treats dendrimer generation size and surface functional group on the aqueous solubility, and therefore, bioavailability of the calcium channel blocking agent nifedipine has been studied using ����� dendrimers with eda oi dendrimerconc vw fig molecular structure of indomethacin and its solubility profiles in glyburide description the presence of differing concentrations of gnhz, ?