paclitaxelloaded dqasomes uj day after tumor implantation fig tumor growth inhibition study in nude mice implanted with human colon cancer cells the mean tumor volume from each group was blotted against the number of days each group involved animals for clarity, error bars were omitted note that after weeks the dose, normalized caffeine snus for paclitaxel, was tripled in all treatment groups empty dqasomes do not show any impact on tumor growth, paclitaxelloaded dqasomes with paclitaxel and dequalinium caffeine snus concentrations identical to controls seem to caffeine snus inhibit the tumor growth by about correspondingly, the average tumor weight in the treatment group, after sacrificing the animals days, later was approximately caffeine snus half of that in all controls although this result seems to suggest that dqasomes might indeed be able to increase the therapeutic potential of paclitaxel, the preliminary character of this first in vivo study has to caffeine snus be emphasized experiments to optimize the treatment protocol are ongoing in the authors laboratory summary since their initial description in , dqasomes and dqasomelike vesicles caffeine snus have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as caffeine snus small drug molecules towards mitochondria within caffeine snus living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for caffeine snus the treatment of cancer and for the therapy of a multitude of mitochondrial diseases acknowledgments i am grateful to prof v p torchilin for many helpful discussions and for his strong and continuous support of my work i also would like to sincerely thank my graduate students, gerard dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has made the writing of this chapter possible i am obliged to the caffeine snus muscular dystrophy association tucson, az, the united mitochondrial disease foundation pittsburgh, pa, mitovec, inc boston, ma and northeastern university boston, ma for the financial support i received from these organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and caffeine snus hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res how to purchase cialis online � smith ra, porteous cm, gane am and murphy mp delivery of bioactive molecules to mitochondria in vivo proc natl acad sci usa murphy mp and smith ra drug delivery to mitochondria the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers caffeine snus rn, taylor rw, wilce ia and murphy mp targeting large molecules to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria caffeine snus as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna delivery crit rev ther drug carr caffeine snus syst weissig v, cheng sm and dsouza g mitochondrial pharmaceutics mitochondrion weissig v targeted drug delivery to mammalian mitochondria in living cells exp opin drug del weissig v, boddapati sv, caffeine snus dsouza ggm and cheng sm targeting caffeine snus of low molecular weight drugs to mammalian mitochondria drug des rev de caffeine snus rosa m, gambacorta a and gliozi a structure, biosynthesis, and physico chemical caffeine snus properties of archaebacterial lipids microbiol rev gambacorta a, gliozi a and de rosa m archaeal lipids and their biotechnological applications world j microbiol biotechnol weissig v, mogel hj, wahab m and lasch j computer simulations of dqasomes proc intl symp control rel bioact mater weissig v, lizano � and torchilin vp a micellar delivery system for dequalinium � a lipophilic cationic drug with anticarcinoma activity caffeine snus j lipos res weissig v, lizano c, ganellin cr and torchilin vp caffeine snus dna binding cationic bolasomes with delocalized caffeine snus charge center a structureactivity relationship study stp pharma sci chrzanowskalightowlers zm, lightowlers caffeine snus rn and turnbull dm gene therapy for mitochondrial dna defects is it possible?